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Safety and Efficacy of Measles, Mumps, Rubella Vaccination in Pediatric Heart Transplantation Patients | Clinical Trials | Clareo Health

RECRUITINGPHASE4

Safety and Efficacy of Measles, Mumps, Rubella Vaccination in Pediatric Heart Transplantation Patients

NCT07195032•Children's Mercy Hospital Kansas City

View on ClinicalTrials.gov

Summary

The study is an interventional, non-randomized assessment of safety and efficacy of live Measles, Mumps and Rubella (MMR) vaccine in subjects aged 12-months to 17 years who have undergone heart transplantation. Subjects who provide permission/assent will receive the commercial MMR vaccine according to product indication and labeling.

Eligibility

Age

1 - 17 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Received a heart transplant
•At least 1 year after transplant
•At least 1 year after antibody-mediated rejection treatment (intravenous immune globulin, rituximab, bortezomib, plasmapheresis, carfilzomib, eculizumab, daratumumab)
•At least 1 year from anti-thymocyte globulin
•At least 6 months after pulse dose steroid treatment or basiliximab treatment
•No history of MMR vaccination OR History of MMR vaccination but seronegativity for measles at time of inclusion
•Clinically well

Exclusion Criteria

•History of repeated infections necessitating adjustment in immunosuppression to non-standard regimen, including single agent immunosuppression and modified trough levels.
•History of anaphylactic reaction to MMR vaccination

Locations (1)

Children's Mercy Hospital

Kansas City, Missouri, United States

Key Dates

Start Date

September 11, 2025

Primary Completion Date

September 11, 2027

Completion Date

September 11, 2027

Last Updated

September 26, 2025

Enrollment

ESTIMATED participants

Conditions

Heart Transplant Infection Prevention

Interventions

Commercial measles, mumps, and rubella (MMR) vaccine

DRUG