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Association Between Cognitive Fraility and Blood and CSF Biomarkers in Older Orthopedic Patients Under Regional Anesthesia
this study aimed to investigate the association between cognitive fraility and selected plasma and cerebrospinal fluid biomarkers related to neurodegenetaion and neuroinflammation in older adult patients undergoing elective orthopedic surgery. The main questions it aims to answer is: * Can biomarkers indicating neurodegeneration and neuroinflammation be correlated with preoperative frailty and cognitive functions? * Can these biomarkers be used as potential tools for early identification in vulnarable populations?
It is a cross sectional study
Age
65 - No limit years
Sex
ALL
Healthy Volunteers
No
Baskent University Ankara Hospital
Ankara, Turkey (Türkiye)
Start Date
June 3, 2021
Primary Completion Date
September 4, 2022
Completion Date
September 4, 2022
Last Updated
September 19, 2025
129
ACTUAL participants
assessment Mini mental state examination
BEHAVIORAL
assessment FRAIL scale
BEHAVIORAL
collecting cerebrospinal fluid during regional anesthesia
OTHER
Lead Sponsor
Baskent University
Data Source & Attribution
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Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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View ClinicalTrials.gov Terms and ConditionsNCT04123314