Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock

Exclusion Criteria

• •Septic shock for more than 12 hours at the time of screening
• •Primary cause of hypotension not due to sepsis (e.g., acute bleeding)
• •Decision not to resuscitate (or to limit full care) or not to intubate taken before obtaining consent
• •Death is deemed to be imminent or inevitable or patients with an underlying disease process with a life expectancy of less than 3 months
• •Anticipated surgery during the first 24 hours after randomization
• •Patient or their relatives' refusal to participate
• •Patients participating in another RCT with interventions possibly compromising the primary outcome
• •Prior enrollment in the CARBON trial
• •Known to be pregnant.
• •Legal protection (i.e., incompetence to provide consent and no guardian or incarceration)
• •No affiliation with the French health care system