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Motivate Vaccinate Activate: An Effectiveness-Implementation Trial to Assess the Impact of a Multi-Component Community-Based Intervention to Increase RSV Vaccine Uptake Among Latino Older Adults
In collaboration with community-based organizations, this study will focus on increasing RSV vaccine use among Latinos. The study will determine how effective community health worker counseling and text-message approaches are to (1) increase RSV vaccine use among older adults (Motivate phase) and (2) encourage younger adults to discuss RSV vaccination with their older friends and family members (Activate phase).
In this type 1 hybrid-implementation study, the investigators will utilize a well-established community-academic partnership to achieve multiple aims. In the Motivate phase, the study will randomize 400 Latino older adults to community health worker (CHW) counseling and text message nudges vs. CHW delivered RSV vaccine vs. text-message nudges alone. The primary outcome in the Motivate phase is RSV vaccine uptake. In the Activate phase, using a parallel design, investigators will randomize 350 Latino adults (18-49 years) to CHW 'activation' counseling to encourage them to discuss RSV vaccine with people over 50 and older in their network plus text-message nudges, vs. text-message nudges alone. The primary outcome for the Activate phase is the average proportion of older adults in participants' social network with whom they discussed RSV vaccination. Interventions in both phases will be adapted using community-based participatory research principles.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
Yes
University of California, San Francisco
San Francisco, California, United States
Start Date
September 10, 2025
Primary Completion Date
November 1, 2028
Completion Date
November 1, 2028
Last Updated
September 30, 2025
750
ESTIMATED participants
Motivate Aim: CHW text message reminders and counseling
BEHAVIORAL
Motivate Aim: CHW text message reminders only
BEHAVIORAL
Activate Aim: CHW text message reminders and counseling
BEHAVIORAL
Activate Aim: CHW text message reminders only
BEHAVIORAL
Lead Sponsor
University of California, San Francisco
Collaborators
Data Source & Attribution
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