Age

18–65

Sex

ALL

Healthy volunteers

Not accepted

Diagnosis of migraine for at least 6 months, according to ICHD-3 criteria
Age between 18 and 65 years
Inadequate response to preventive therapy used regularly for at least 3 months
Planned treatment with greater occipital nerve block (GONB) and provision of signed informed consent
Receiving GONB treatment for the first time

Pregnancy or breastfeeding
Presence of malignancy
Coagulopathy or anticoagulant therapy
Local infection, open wound, or history of surgery at the injection site preventing the procedure
History of severe neurological or psychiatric disorders
Receipt of interventional treatment (e.g., Botox, acupuncture, neural therapy, nerve blocks) within the last 3 months
Use of steroids or immunosuppressive therapy
Start of a new preventive therapy within the last 3 months
Inability to comply with keeping a headache diary
Known hypersensitivity or allergy to bupivacaine

Predictors of GON Blockade Success in Migraine