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Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study) | Clinical Trials | Clareo Health

RECRUITING

Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study)

NCT07167225•Roswell Park Cancer Institute

View on ClinicalTrials.gov

Summary

This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use behaviors of consumers.

Detailed Description

PRIMARY OBJECTIVE: I. To evaluate differences in self-reported nicotine and cannabis use behaviors and biomarkers of exposure to toxicants and carcinogens by product use status, to generate effect sizes required to calculate sample sizes needed for a larger study.

Eligibility

Age

18 - 25 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Young adult (18-25 years old).
•Ability to read and write in English.
•Participants must fall into one of the following groups (based on self-report):
•Predominant e-cigarette consumer: defined as using nicotine-containing e-cigarettes daily for the past six months but not having used other nicotine containing products more than weekly or cannabis products for the past month.
•Predominant cannabis consumer: defined as using cannabis at least 3x/week for the past six months in any form, including smoking, vaping, and oral use, with no more than weekly use of any nicotine or tobacco products.
•E-cigarette-cannabis co-consumers: defined as daily use of nicotine e-cigarettes and use of cannabis at least 3x/week, including smoking, vaping, and oral use, for at least the past six months, with no use of other nicotine containing products more than weekly.
•No self-reported diagnosis of kidney disease (current, or within the past year prior to the study visit).
•Participants must understand the voluntary nature of this study and sign a written informed consent form before proceeding with study activities.

Exclusion Criteria

•Individuals under the age of 18 or over the age of 25.
•Currently pregnant or breastfeeding (female participants).
•Unwilling or unable to follow protocol requirements

Locations (1)

Roswell Park Comprehensive Cancer Center

Buffalo, New York, United States

Key Dates

Start Date

April 3, 2025

Primary Completion Date

September 1, 2028

Completion Date

September 1, 2028

Last Updated

October 3, 2025

Enrollment

150

ESTIMATED participants

Conditions

Cigarette Smoking-Related CarcinomaE-Cig Use

Interventions

Effectiveness of different recruitment approaches

OTHER

Choice of study completion locations

OTHER

Cannabis Engagement Assessment

OTHER

E-cigarette dependence Scale

OTHER

Contacts

ASK RPCI

CONTACT

1-800-767-9355 askroswell@roswellpark.org

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 3, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use E-cigarettes and Cannabis (Co-Tox Study)

Inclusion Criteria

Exclusion Criteria

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