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Genicular Nerve Block for Knee Pain in the ED | Clinical Trials | Clareo Health

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RECRUITINGNANCT07158736

Genicular Nerve Block for Knee Pain in the ED

Patient with atraumatic knee pain without a large knee effusion on x-ray will be randomized to receive either a genicular nerve block (GNB) or standard of care in the emergency department.

Lead sponsor: University of Pennsylvania•4 U.S. locations•View source on ClinicalTrials.gov

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Contacts

Umar Clinical Research Coordinator, AB

CONTACT

267-624-4394 umar.aulia@pennmedicine.upenn.edu

Sponsors

Lead Sponsor

University of Pennsylvania

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Atraumatic knee pain
•\>17 years age
•X-ray of the knee obtained in the ED
•Initial pain score (numeric rating scale) 5-10

Exclusion Criteria

•Fracture or dislocation on x-ray
•large knee joint effusion identified on x-ray
•allergy or contraindication to local anesthetics
•History of local anesthetic systemic toxicity after receiving local anesthetics
•Pregnancy
•Incarcerated
•History of knee replacement of affected knee
•Concern for septic joint
•Overlying cellulitis
•Hemodynamic instability
•Altered mental status or inability to consent for procedure.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: February 12, 2026Terms

Trial snapshot

StatusRECRUITING

PhaseNA

Enrollment34

Start dateAug 2025

Last updatedFeb 12, 2026

Condition

Locations shown

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania

Pennsylvania Hospital

Philadelphia, Pennsylvania

Pennsylvania Presbyterian Medical Center

Philadelphia, Pennsylvania

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 12, 2026Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions