Loading clinical trials...

Long Term Effect of Brain Stimulation in PPA | Clinical Trials | Clareo Health

RECRUITINGNA

Long Term Effect of Brain Stimulation in PPA

LONG-TERM EFFECT OF TRANSCRANIAL MAGNETIC STIMULATION AND TRANSCRANIAL ELECTRICAL STIMULATION IN PRIMARY PROGRESSIVE APHASIA: RANDOMIZED, DOUBLE-BLIND CLINICAL TRIAL (RECONNECT-PLUS)

NCT07158216•Hospital San Carlos, Madrid

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to investigate the effect of non-invasive brain stimulation techniques in the progression of primary progressive aphasia for 6 months. We will compare three modalities of brain stimulation (TMS, tDCS, TMS+tDCS) against sham stimulation. All patients will receive also language therapy.

Detailed Description

Transcranial Magnetic Stimulation will follow an intermitent theta-burst protocol targetting the left dorsolateral prefrontal cortex. Transcranial electrical stimulation will also follow an excitatory protocol over the same region. All brain stimulation procedures will be conducted under neuronavigation. Language therapy will follow the lexical retrieval cascade protocol and will be conducted after each brain stimulation session.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Diagnosis of PPA according to the current consensus criteria supported by neuroimaging (FDG-PET or MRI) (Gorno-Tempini et al., 2011);
•Clinical Dementia Rating scale equal or less than 1;
•The language impairment is the main neurological deficit for the patient.

Exclusion Criteria

•Patient diagnosed with a condition other than PPA that could cause language impairment;
•History of epilepsy or presence of focal epileptiform pathology on EEG recording; ·Contraindications related to the treatments or procedures to be used (TMS and tDCS), such as ferromagnetic material, pregnancy, or breastfeeding;
•Terminal illness or active malignancy;
•Alcohol or substance abuse within the past year;
•Major psychiatric disorders (schizophrenia, schizoaffective disorders, bipolar disorder, obsessive-compulsive disorder, or personality disorders);
•Absolute inability to communicate (mutism), or poor command of the language that, in the investigator's judgment, would prevent participation in the study;
•Severity of PPA that prevents participation in interventions or assessments at the time of inclusion;
•Participation in another clinical trial within the previous 4 months;
•Chronic use of medications that could affect study outcomes;
•Antiepileptic drugs: allowed if on stable doses for at least 3 months before inclusion. If needed during the study due to seizure occurrence, they may be added;
+4 more criteria

Locations (1)

Hospital Clinico San Carlos

Madrid, Spain

Key Dates

Start Date

September 15, 2025

Primary Completion Date

December 1, 2028

Completion Date

December 1, 2028

Last Updated

September 11, 2025

Enrollment

ESTIMATED participants

Conditions

Primary Progressive Aphasia(PPA)

Interventions

TMS

DEVICE

tDCS

DEVICE

Sham TMS

DEVICE

Sham tDCS

DEVICE

Contacts

Jordi Matias-Guiu, PhD MD

CONTACT

+34913303000 jordi.matias-guiu@salud.madrid.org

Speech and Language Interventions for Italian People With PPA

NCT06739967

Primary Progressive Aphasia(PPA)

View study

RECRUITING

UPenn Observational Research Repository on Neurodegenerative Disease

NCT04715399

Frontotemporal Degeneration(FTD)Primary Progressive Aphasia(PPA)+7 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 11, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Long Term Effect of Brain Stimulation in PPA

Inclusion Criteria

Exclusion Criteria

Speech and Language Interventions for Italian People With PPA

UPenn Observational Research Repository on Neurodegenerative Disease

Targeted Transcranial Magnetic Stimulation to Improve Language and Speech in Patients With Primary Progressive Aphasia