An Observational Study on Lecanemab Treatment for Early Alzheimer's Disease

Inclusion Criteria

• •Mild Alzheimer's Disease (AD):
• •1. Age ≥ 45 years but ≤ 85 years;
• •2. Literacy level of elementary school and above (i.e., ≥3 years of education);
• •3. Fulfillment of the diagnostic criteria for probable AD in the NINCDS-ADRDA 2007 revision (or the diagnostic criteria for clinically probable AD in the National Institute on Aging and Alzheimer's Disease Association NIA-AA 2011 edition);
• •4. Clinical Dementia Rating Scale CDR-global = 1 point;
• •5. Aβ-PET scan suggesting extensive deposition of Aβ plaques in the brain.
• •1. Age: 45 years or older but ≤85 years;
• •2. Literacy level elementary school and above (i.e., ≥3 years of education);
• •3. Meeting Peterson's 2004 diagnostic criteria for MCI:
• •(i) Complaint of memory impairment that can be confirmed by an informed person; (ii) objective evidence of memory impairment (memory test scores 1-1.5 standard deviations below normal controls matched for age and literacy; e.g., Huashan Hospital's recommended cut-off values for those with elementary school literacy or above are as follows: long-delayed recall 50-59 years old ≤ 5, 60-69 years old ≤ 4, 70-79 years old ≤ 3, 80-89 years old ≤ 2, or re-recognition scores of 50-59 years old ≤ 20, 60-69 age ≤19 points, 70-79 years ≤18 points, 80-89 years ≤16 points); (iii) Overall cognitive functioning was largely preserved, with CDR-global = 0.5 points and MMSE: ≥24 points for those with junior high school or higher education used in this study;
• •④ Daily life ability remains normal (basically able to complete going out by transportation and shopping and counting, etc.);
• •⑤ Does not meet the International Classification of Diseases Diagnostic Manual, 10th edition dementia criteria (for research purposes) and the National Institute of Neurological and Speech-Language Disorders and Stroke, Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) likely diagnostic criteria for AD dementia; (vi) Aβ-PET scan suggested extensive deposition of Aβ plaques in the brain.
• •1. Age ≥55 years but ≤85 years;
• •2. Elementary school 3 years of education and above;
• •3. MMSE: ≥26 points for those with junior high school or higher education;
• •4. CDR=0;
• •5. Activity of Daily Living Scale (ADL) score ≤ 20;
• •6. No significant deposition of Abeta in the brain as indicated by Aβ-PET scan.