The Effects of Clostridium Butyricum on Adverse Events During Adjuvant Chemotherapy for Colorectal Cancer

Exclusion Criteria

• •Use of probiotics, prebiotics, synbiotics, or antibiotics within 2 weeks prior to enrollment;
• •Presence of psychiatric disorders or other conditions that prevent cooperation with the intervention;
• •Dysfunction of vital organs such as the liver, kidneys, or heart that renders the individual unsuitable for clinical research upon assessment, or inadequate bone marrow, liver, or renal function to undergo adjuvant therapy;
• •Participation in other clinical studies within 3 months prior to enrollment;
• •History of inflammatory bowel disease;
• •History of autoimmune diseases;
• •Pregnancy or breastfeeding;
• •Receipt of neoadjuvant therapy (including chemotherapy, radiotherapy, or targeted therapy) prior to surgery;
• •Underwent ostomy surgery during the operation (including temporary or permanent ostomy).