To Observe the CD7-targeted CAR-T Therapy in the Treatment of r/r PTCL

Exclusion Criteria

• •1. Primary cutaneous T-cell lymphoma, including mycosis fungoides (MF) and Sezary syndrome (SS); T-lymphoblastic leukemia/lymphoma（T-ALL/LBL）；
• •2. Primary central nervous system cell lymphoma, or with active central nervous system invasion；
• •3. If anti-tumor treatment has been received before infusion, and drugs have not been completely eliminated must be excluded;
• •4. Individuals with a history of allergies to any component in cellular products.
• •5. Cardiac function:cardiac dysfunction classified as Class III or IV；Myocardial infarction, cardiac angioplasty or stenting, unstable angina pectoris, or other serious heart disease clinically within 12 months of enrollment；The electrocardiogram indicates that the QT interval is significantly prolonged, and the patient has serious heart disease such as serious arrhythmia in the past.
• •6. Previous history of craniocerebral trauma, Disorders of consciousness, epilepsy, cerebrovascular ischemia, cerebrovascular hemorrhagic disease, etc.
• •7. Uncontrolled severe active infections.
• •8. The subject has a history of other primary cancers, except for the following.
• •9. Subjects with autoimmune diseases requiring treatment or subjects requiring Immunosuppressive drug treatment.
• •10. Individuals with graft versus host disease (GvHD) and/or requiring immunosuppressive therapy.
• •11. Live vaccination within 4 weeks prior to screening.
• •12. The subject has a history of alcoholism, drug abuse, or mental illness.
• •13. Individuals with EBV DNA copy numbers greater than the upper limit of normal or positive for EBER; CMV copies greater than the upper limit of normal values; HBV or HCV DNA copy number\>the upper limit of normal value, and active syphilis or AIDS and other virus infected persons.
• •14. Subjects who were receiving systemic hormone treatment before screening and who were judged by the investigator to need long-term use of systemic hormone during treatment (except for inhalation or local use).
• •15. Individuals who have participated in other clinical trials within the first 4 weeks of screening.
• •16. Pregnant and lactating women and subjects with Fertility who cannot take effective contraceptive measures (both men and women).
• •17. Any situation that the researcher believes may increase the risk of the subject or interfere with the test results.