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Dinalbuphine Sebacate in Postoperative Pain Control After TKA | Clinical Trials | Clareo Health

NOT_YET_RECRUITINGPHASE4

Dinalbuphine Sebacate in Postoperative Pain Control After TKA

Effectiveness of Dinalbuphine Sebacate in Postoperative Pain Control Following Total Knee Arthroplasty: A Randomized Double Blinded Placebo-controlled Trial

NCT07140510•Thammasat University

View on ClinicalTrials.gov

Summary

To evaluate the effectiveness of Dinalbuphine Sebacate for controlling subacute pain after total knee arthroplasty

Detailed Description

A single dose of intramuscular Dinalbuphine Sebacate can mitigate pain for up to 1 week after TKA

Eligibility

Age

50 - 90 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Osteoarthritic knee patients underwent unilateral primary TKA
•Age 50-90 years
•ASA class I-III
•Participants understand and consent to the protocol of the trial

Exclusion Criteria

•Morbid obesity (BMI\>40)
•Knee osteoarthritis from inflammatory knee arthritis, trauma, infection
•Previous knee surgery
•Cognitive disorder
•Liver disease
•Allergy to NSAIDs, opioids, sesame oil, and benzyl benzoate
•CYP3A4 inhibitor and inducer drugs used

Locations (1)

Thammasat University

Khlong Luang, Changwat Pathum Thani, Thailand

Key Dates

Start Date

October 1, 2025

Primary Completion Date

June 1, 2026

Completion Date

September 1, 2026

Last Updated

August 24, 2025

Enrollment

100

ESTIMATED participants

Conditions

Osteo Arthritis of the KneeTotal Knee Anthroplasty

Interventions

Dinalbuphine Sebacate

DRUG

Normal Saline

DRUG

Contacts

Supakit Kanitnate, M.D.

CONTACT

+66 899853635 naypeng@hotmail.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 24, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Dinalbuphine Sebacate in Postoperative Pain Control After TKA

Inclusion Criteria

Exclusion Criteria

COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty

Drain Removal Before Versus After CPM in Primary Total Knee Arthroplasty

The Effect of Kinesio Taping on Mobility, Pain, Balance and Daily Activities in Total Knee Replacement Patients

Early Clinical and Radiological Outcomes of a Novel Robotic TKA System

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