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Advanced Cardiovascular Management in Major Non-cardiac Surgery. | Clinical Trials | Clareo Health

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Advanced Cardiovascular Management in Major Non-cardiac Surgery.

Advanced Cardiovascular Management in Major Non-cardiac Surgery. A Single Center, Randomized, Parallel, Open Label Clinical Trial

NCT07134530•Fondazione IRCCS Policlinico San Matteo di Pavia

View on ClinicalTrials.gov

Summary

This is a single center, randomised and controlled clinical triaI whose aim is to predict and treat in advance, intraoperative hypotension episodes. In particular, the aim of the study is to compare the clinical impact of two different hemodynamic strategies based on the use of different monitoring platforms: the Edwards EV1000 equipped with FloTrac sensor and HemoSphere platform equipped with Acumen Hypotension Prediction Index software and Acumen IQ pressure sensor.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Informed Consent as documented by signature (Appendix Informed Consent Form)
•Age ≥ 18 years old
•Surgical indication for major NCS needing general anesthesia
•Anaesthesiologic indication for perioperative arterial cannulation and advanced hemodynamic monitoring

Exclusion Criteria

•Informed Refusal as documented by signature (Appendix Informed Consent Form)
•Age ≤ 18 years old
•Severe aortic valvulopathy
•Atrial fibrillation

Locations (1)

Fondazione IRCCS Policlinico San Matteo di Pavia

Pavia, Pavia, Italy

Key Dates

Start Date

April 29, 2024

Primary Completion Date

April 1, 2026

Completion Date

April 1, 2026

Last Updated

August 21, 2025

Enrollment

534

ESTIMATED participants

Conditions

Intraoperative Hypotension

Interventions

HPI-driven intraoperative hemodynamic management strategy

DEVICE

GDT strategy

DEVICE

Continuous Finger-cuff Arterial Pressure Monitoring and Intraoperative Hypotension During Non-cardiac Surgery: the Randomized DETECT II Trial

NCT06753097

Intraoperative Hypotension

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COMPLETEDNA

Do Compression Stockings Used During Cesarean Sections Affect Intraoperative Hypotension and Nausea?

NCT06707428

Intraoperative Hypotension

View study

COMPLETEDNA

Continuous Versus Bolus Administration of Norepinephrine to Treat Hypotension During Anesthetic Induction

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 21, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Advanced Cardiovascular Management in Major Non-cardiac Surgery.

Inclusion Criteria

Exclusion Criteria

Continuous Finger-cuff Arterial Pressure Monitoring and Intraoperative Hypotension During Non-cardiac Surgery: the Randomized DETECT II Trial

Do Compression Stockings Used During Cesarean Sections Affect Intraoperative Hypotension and Nausea?

Continuous Versus Bolus Administration of Norepinephrine to Treat Hypotension During Anesthetic Induction

Phenylephrine and Pulse Pressure Variability

Perioperative Personalized Blood Pressure Management

Intraoperative Hypotension and Post-anesthesia Care Unit Recovery