Cholangitis Definition and Treatment After Kasai Hepatoportoenterostomy for Biliary Atresia: TRACK-BA Study (TRacking Cholangitis Post Kasai in Biliary Atresia)

This prospective, observational study will be conducted across hospitals managing pediatric biliary atresia patients. Data on suspected cholangitis cases in the first year post Kasai hepatoportoenterostomy will be collected by mini-teams of three healthcare providers over twelve months. Data will be anonymized, and the study will adhere to international ethical standards. Inclusion Criteria: * Patients with biliary atresia suspected of cholangitis within one year post Kasai hepatoportoenterostomy. * Data from specialties including pediatric surgery, pediatric hepatology, and pediatric emergency care. Exclusion Criteria: • Recurrent cholangitis or cholangitis after one-year post Kasai hepatoportoenterostomy. Definitions: Cholangitis will be defined by clinical confirmation, improvement with antimicrobial therapy, and lab value changes. Primary Aim: To assess the application of consensus definitions for suspected and confirmed cholangitis. Secondary Aim: To evaluate the proposed duration of treatment for cholangitis and compare it to clinical practice. Data Collection: Data will be stored using the secure REDCap platform, managed by the University of Geneva. Local investigators are responsible for ethical approvals. Expected Results: This study will assess the practicality of applying expert panel definitions for cholangitis after Kasai hepatoportoenterostomy and gather feedback from clinicians. A sample size of 40 patients is targeted, with 20 in each group (suspected and confirmed). Findings will help refine diagnostic criteria.