A Phase I/II Study on Safety AND Immunogenicity of AZD4117 and AZD5315 Vaccines (PANDA)

Exclusion Criteria

• •History of hypersensitivity to any component of the IMP
• •History of hypersensitivity to penicillin and its derivatives
• •History of severe adverse reaction and/or severe allergic reaction (eg, anaphylaxis associated with a vaccine
• •Known or suspected congenital or acquired immunodeficiency
• •Abnormal findings on screening laboratory tests
• •Previous history of myocarditis, pericarditis, Guillain-Barré syndrome or any other demyelinating condition
• •Known or suspected autoimmune conditions as determined by history and/or physical examination
• •Receipt of any other type of seasonal influenza vaccination from 14 days before the first dose until 28 days after the administration of the last dose of IMP
• •Receipt of an mRNA vaccine within 28 days before administration of IMP
• •Receipt or expected receipt of any other type of licensed or investigational vaccine within 28 days prior to Visit 1 (D1) or Visit 5 (D58)
• •Receipt of immunoglobulin or blood products within 6 months prior to administration of study intervention or expected receipt during the study
• •Receipt of immune-modifying drugs or immunosuppressive therapy, such as anti-cancer chemotherapy or radiation therapy within 6 months prior to enrollment (or expected receipt during study), or long-term systemic corticosteroid therapy (prednisolone or equivalent at a dose of ≥ 20 mg daily for more than 2 consecutive weeks) within 6 months prior to enrollment or expected receipt during study. Topical/inhaled steroids or short-term oral steroids are permitted
• •Participation in another trial, or receiving interventional Study IMP, in the preceding 90 days or expected receipt of another study intervention (or participation in another trial) during the period of study follow-up
• •Acute (time-limited) or febrile (temperature ≥ 38.0 °C \[100.4 °F\]) illness/infection within 3 days of intended IMP administration
• •Individuals who have had a previous confirmed or suspected illness from influenza caused by an H5N1 or H7N9 virus
• •Individuals who had household contact with and/or intimate exposure to an individual with laboratory confirmed H5N1 infection, exposure to infected household poultry/ wild birds/cattle or contaminated environments with sick and dead poultry or wild birds or cattle, within 60 days prior to enrollment
• •Female participants who are pregnant, lactating, or of childbearing potential and not using a highly effective method of contraception or abstinence from at least 4 weeks prior to IMP administration and until at least 6 months after IMP administration