Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
AstraZeneca
With
Biomedical Advanced Research and Development Authority
Joint Program Executive Office Chemical, Biological, Radiological, and Nuclear Defense Enabling Biotechnologies
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Adults, ≥ 18 years of age at the time of signing the informed consent
Participants who are medically stable such that, according to the judgement of the Investigator, hospitalization within the study period is not anticipated and the participant appears likely to be able to remain on study through the end of protocol-specified follow-up. A stable medical condition is defined as disease not requiring significant change in therapy or hospitalization for worsening disease during the 3 months prior to enrollment
Written informed consent and any locally required authorization (eg, HIPAA in the US) obtained from the participant prior to performing any protocol-related procedures, including screening evaluations
You may not be if
History of hypersensitivity to any component of the IMP
History of hypersensitivity to penicillin and its derivatives
History of severe adverse reaction and/or severe allergic reaction (eg, anaphylaxis associated with a vaccine
Known or suspected congenital or acquired immunodeficiency
Abnormal findings on screening laboratory tests
Previous history of myocarditis, pericarditis, Guillain-Barré syndrome or any other demyelinating condition
Known or suspected autoimmune conditions as determined by history and/or physical examination
Receipt of any other type of seasonal influenza vaccination from 14 days before the first dose until 28 days after the administration of the last dose of IMP
Receipt of an mRNA vaccine within 28 days before administration of IMP
Receipt or expected receipt of any other type of licensed or investigational vaccine within 28 days prior to Visit 1 (D1) or Visit 5 (D58)
Receipt of immunoglobulin or blood products within 6 months prior to administration of study intervention or expected receipt during the study
Receipt of immune-modifying drugs or immunosuppressive therapy, such as anti-cancer chemotherapy or radiation therapy within 6 months prior to enrollment (or expected receipt during study), or long-term systemic corticosteroid therapy (prednisolone or equivalent at a dose of ≥ 20 mg daily for more than 2 consecutive weeks) within 6 months prior to enrollment or expected receipt during study. Topical/inhaled steroids or short-term oral steroids are permitted
Participation in another trial, or receiving interventional Study IMP, in the preceding 90 days or expected receipt of another study intervention (or participation in another trial) during the period of study follow-up
Acute (time-limited) or febrile (temperature ≥ 38.0 °C \[100.4 °F\]) illness/infection within 3 days of intended IMP administration
Individuals who have had a previous confirmed or suspected illness from influenza caused by an H5N1 or H7N9 virus
Individuals who had household contact with and/or intimate exposure to an individual with laboratory confirmed H5N1 infection, exposure to infected household poultry/ wild birds/cattle or contaminated environments with sick and dead poultry or wild birds or cattle, within 60 days prior to enrollment
Female participants who are pregnant, lactating, or of childbearing potential and not using a highly effective method of contraception or abstinence from at least 4 weeks prior to IMP administration and until at least 6 months after IMP administration
Clareo Health | A Phase I/II Study on Safety AND Immunogenicity of AZD4117 and AZD5315 Vaccines (PANDA)
