A Study of HDM2005 in Combination With Standard of Care in Patients With Diffuse Large B-Cell Lymphoma

Exclusion Criteria

• •1. Known active central nervous system (CNS) lymphoma.
• •2. Prior of allogeneic hematopoietic stem cell transplantation and has acute or ongoing graft-versus-host disease (GVHD) of any grade.
• •3. Known additional malignancy that is progressing or has required active treatment within the past 3 years.
• •4. History of severe bleeding disorders.
• •5. History of interstitial lung disease or radiation pneumonitis.
• •6. Prior solid organ transplant.
• •7. Ongoing Grade \>1 treatment-related adverse events.
• •8. Current or history of clinically significant cardiovascular and cerebrovascular diseases.
• •9. Active infection requiring systemic therapy.
• •10. Concurrent active HBV or HCV infection or known history of human immunodeficiency virus (HIV) infection.
• •11. Prior ROR1-targeted therapy.
• •12. Ongoing corticosteroid therapy.
• •13. Current active autoimmune disease or history of autoimmune disease requiring treatment.
• •14. History of drug anaphylaxis or severe food allergy.
• •15. Any history or current evidence of disease, treatment, or laboratory abnormality as determined by the investigator that may affect the study results, interfere with the subject's full participation in the study, or be contrary to the subject's best interests.