PHArmaCokinetics of methYLphenidate in Adult Patients With Attention-Deficit /Hyperactivity Disorder

The various phases of the study will take place at the Tours University Hospital: * Patient selection (Department of Addictions): Eligibility assessment by the psychiatrist consulting patients with ADHD. Information regarding the study, risks, and constraints associated with the study. * Patient inclusion (CIC 1415): Signed consent after informing the patient about the protocol, risks, and constraints. Collection of demographic and medical data, ADHD symptom intensity (ASRS-18), and individual psychological characteristics (emotional dysregulation: DERS-36, impulsivity: UPPS-P, binge eating disorder: BES). * Clinical and laboratory assessments prior to MPH administration (CIC 1415): Blood pressure, NPF, serum creatinine, and complete liver function tests. * MPH administration (CIC 1415): MPH LP is taken at the patient's usual dosage in the early morning. * Repeated blood samples (CIC 1415) to measure plasma concentrations of MPH and APP before drug administration (T0), i.e., a pre-administration sample, then at T30 minutes (+/- 10 min), T1h (+/- 10 min), T2h (+/- 30 min), T3h (+/- 30 min), T4h (+/- 30 min), T6h (+/- 30 min), and T8h (+/- 30 min) after MPH administration. Clinical Research Nurses will accurately note the exact sampling times on the venous sampling accompanying sheets, including any differences from the theoretical schedule, in order to limit bias. Samples will be collected using sodium heparin trace element tubes, without separator gel (royal blue cap with black collar). These venous samples will be sent to and stored at the Biological Resources Center of Touraine (CRB-T). In addition, two aliquots must be taken and stored by the CRB-T. For each sample, one aliquot must be sent to the Medical Pharmacology Department and the second retained for safety. * Assessment of perceived efficacy and tolerance of treatment (CIC 1415): visual analog scale allowing self-assessment of ADHD symptoms according to the patient at T0, T30 minutes, T1h, T2h, T3h, T4h, T6h, T8h and the effect on food craving; clinical assessment of treatment tolerance at T4h and T8h. * Patient discharged home, in the absence of serious adverse side effects. * Pharmacokinetic analysis and modeling (Medical Pharmacology Department): transfer from the CRB-T at the end of the study, plasma assays, pharmacokinetic modeling based on patient data. * Note: For pharmacokinetic analysis, 6 mL of blood will be collected in sodium heparin tubes over the 8 sampling times. A total of 48 mL of blood will therefore be collected per patient on their day of participation. These samples will ultimately be destroyed after the results have been analyzed.