Loading clinical trials...

Efficacy of Four Topical Products to Improve Skin Longevity | Clinical Trials | Clareo Health

COMPLETEDNA

Efficacy of Four Topical Products to Improve Skin Longevity

A Clinical Study to Determine the Efficacy of Four Test Articles to Improve Skin Longevity Over Eight Weeks Use Period

NCT07118943•Amazentis SA

Summary

The objective of this study is to determine the efficacy of four topical products to improve facial skin longevity over an eight-week use period utilizing analysis of images and self-perception questionnaires.

Eligibility

Age

40 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Healthy female and male volunteers aged 40 to 65 years with no signs of skin disorders.
•Subject is willing and able to read, understand, and provide written Informed Consent and signed photo release.
•Subject has a score of 3.0 to 6.0 for clinically graded visible facial wrinkles using the Fitzpatrick Classification of Facial Wrinkling scale at Baseline, to determine eligibility for the creams or serum test articles or 3.0 to 6.0 for clinically graded visible wrinkles in the eye area using a wrinkling scale for the eye cream test article.
•Subject is willing to refrain from applying/using moisturizer, creams, serums or treatment/anti-aging products to their face during the three days prior to Visit 1 (Baseline). Subject's other regular skin products such as cleanser, sunscreen and cosmetics are acceptable.
•Subject is willing to come to the test facility with a clean face free of makeup and sunscreen prior to all visits.
•Subject is a regular sunscreen user (uses at least 2 times a week).
•Subject is willing to avoid direct sun exposure and/or to apply sunscreen to their face in the event of sun exposure.
•Subject agrees to remove jewelry and false eye lashes before the visits.
•Subject agrees not to introduce any new personal care products or cosmetics to the face while participating on the study.
•Subject is willing to avoid use of tanning beds and any use of sunless tanners on the face throughout the study.
+2 more criteria

Exclusion Criteria

•Female only: Pregnant or lactating or planning a pregnancy during the course of the study. (self-reported).
•Piercing or tattoos including permanent or semi-permanent make-up on the face which may interfere with study assessments.
•Any conditions on the face that would interfere with evaluations (i.e. full beard, scars, open cuts, sunburn, severe hyperpigmentation, facial hair/peach fuzz, etc.) or active acne or acne marks.
•Any skin conditions such as rosacea, eczema, psoriasis, seborrheic dermatitis, vitiligo, etc., or is under the treatment of a doctor for any skin condition on the face.
•Use of a self-tanner/stain on the face within two weeks of the study start.
•Allergies or sensitivities to facial moisturizer products, similar materials or their ingredients or cosmetics.
•Insulin-dependent diabetes.
•Hematological or immune deficiency disease such as HIV positive, AIDS, Systemic Lupus Erythematosus.
•Recent use within the last 14 days of a chemical peel or is currently using an in-home or professional chemical peel on their facial skin.
•Subject has had a cosmetic medical procedure in the test area such as injectable anti-wrinkle products (e.g. Botox), facial cosmetic surgery, etc. in the last year.
+5 more criteria

Locations (1)

Princeton Consumer Research Corp.

Winnipeg, Manitoba, Canada

Key Dates

Start Date

August 12, 2025

Primary Completion Date

October 9, 2025

Completion Date

October 9, 2025

Last Updated

November 17, 2025

Enrollment

132

ACTUAL participants

Conditions

AgingWrinkle

Interventions

Face care product

OTHER

Face care product

OTHER

Face care product

OTHER

Face care product

OTHER

Targeting Aging With a Ketone Ester for Function in Frailty

NCT06645847

Frail ElderlyAging+2 more

View study

RECRUITING

Ultrasound Image Bank: Advancing Medical Research and Diagnostics

NCT07031921

Gynecological ImagingUltrasound Diagnostics+1 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 17, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Efficacy of Four Topical Products to Improve Skin Longevity

Inclusion Criteria

Exclusion Criteria

Targeting Aging With a Ketone Ester for Function in Frailty

Ultrasound Image Bank: Advancing Medical Research and Diagnostics

MRI Study of Musculoskeletal Function

Skin Barrier Function and Inflammation in Aging: The BIA Study

Studies Into Touch in Healthy Humans to Provide Sensory Feedback in Prostheses

Safe-Age Study: A Safety and Tolerability Study of a Nutritional Supplement in Healthy Older Adults