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O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock | Clinical Trials | Clareo Health

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O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock

Oxygen Consumption And Carbon Dioxide Production Following Hemodynamic Optimization In Shock: The OxyCarDio Study

NCT07107724•Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Summary

The goal of this prospective observational study is to analyse change in VO2 and VCO2 measured via a dedicated ventilator after hemodynamic optimization maneuvers in adult patients admitted to the ICU with any sign of shock. The main questions it aims to answer are: 1. Do common maneuvers for hemodynamic optimization (fluid bolus and/or vasopressor administration) have any impact on tissue perfusion in terms of oxygen consumption (VO2) and carbon dioxide production (VCO2) measured by a dedicated ventilator? 2. Are the values measured by exhaled gas comparable to those calculated by the measurement of dissolved veno-arterial gas? Participants enrolled in the study will receive advanced hemodynamic monitoring with MostCare Up (Vygon ®) and their hemodynamic instability will be managed according to most recent guidelines and based on clinical decision of treating physicians.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Hypotension (MAP\< 65mmHg or sudden drop in MAP \> 15 mmHg) and one of the following conditions:
•Heart rate \> 120 bpm
•Urinary output \< 0.5 ml/kg/h for at least two hours
•Lactate \> 2 mmol/L

Exclusion Criteria

•Urgent need for surgery
•Urgent need for veno-arterial ECMO or severe hemodynamic instability
•Consistent risk of imminent death
•Severe ARDS or severe respiratory failure (p/F \< 100 mmHg) and/or FiO2\>0.8
•Severe heart failure (NYHA 4 and/or EF\<25%)
•Need for intermittent or continuous renal replacement therapy (IRRT or CRRT)
•Anemia defined as Hb\<8 g/dL
•VO2 variability \< 5% throughout ten minutes of stabilization before procedure start
•Intraabdominal hypertension, defined as intraabdominal pressure \> 18 mmHg
•Pregnancy
+3 more criteria

Locations (1)

Policlinico Universitario Fondazione Agostino Gemelli IRCCS

Roma, Italy

Key Dates

Start Date

July 29, 2025

Primary Completion Date

July 1, 2027

Completion Date

December 1, 2027

Last Updated

August 6, 2025

Enrollment

ESTIMATED participants

Conditions

Hemodynamic InstabilityOxygen Consumption (V̇O2)

Interventions

Noradrenalin

OTHER

Fluid bolus

OTHER

Contacts

Antonio M Dell'Anna

CONTACT

+39 0630154490 antoniomaria.dellanna@policlinicogemelli.it

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 6, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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O2 Consumption And CO2 Production After Hemodynamic Optimization In Shock

Inclusion Criteria

Exclusion Criteria

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