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Assessment of Right Ventricular Function After Acute Pulmonary Embolism: a Comparison of Speckle Tracking Strain and Conventional Echocardiographic Parameters | Clinical Trials | Clareo Health

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Assessment of Right Ventricular Function After Acute Pulmonary Embolism: a Comparison of Speckle Tracking Strain and Conventional Echocardiographic Parameters

Assessment of Right Ventricular Function for Diagnosis and Prognosis After Acute Pulmonary Embolism: a Comparison of Speckle Tracking Strain and Conventional Echocardiographic Parameters

NCT07107347•Assiut University

View on ClinicalTrials.gov

Summary

Echocardiographic Assessment: Performed within 24h of PE diagnosis Conventional parameters: TAPSE, RV FAC, RV/LV ratio, tricuspid S', PASP STE parameters: RV free wall longitudinal strain (RVFWS), global longitudinal strain (GLS) if feasible All measurements averaged over 3 cardiac cycles (sinus) or 5 (AF) Follow-up data: ICU/hospital LOS Need for vasopressors/mechanical ventilation In-hospital and 30-day mortality

Detailed Description

the study targets patient with acute pulmonary embolism confirmed by CTPA, without hemodynamic instability. within the first 24 hours echocardiography will be conducted, assessment of RV function by conventional measures eg, TAPSE, S', FCA and speckle tracking strain echocardiography. compare the results and its sensitivity in prediction of clinical outcomes, that will be assessed by follow up the patients for one month regarding length of hospital stay, oxygen/ventilatory support, hemodynamics support and 30 day mortality.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Adults ≥18 years.
•2. Confirmed acute PE (via CT pulmonary angiography).(4,6)
•3. Echocardiography performed within 24 hours of diagnosis.

Exclusion Criteria

•1. Pre-existing significant RV dysfunction (e.g., due to chronic pulmonary hypertension, cor pulmonale or congenital heart disease).
•2. History of coronary artery disease.
•3. Impaired LV systolic function, ejection fraction \<50%.
•4. Moderate to severe valvular heart disease.
•5. Prior document of an episode of pulmonary embolism.
•6. Poor acoustic window.
•7. Hemodynamic instability

Locations (1)

Assiut University Hospital

Asyut, Asyut Governorate, Egypt

Key Dates

Start Date

September 1, 2025

Primary Completion Date

September 1, 2027

Completion Date

March 1, 2028

Last Updated

August 14, 2025

Enrollment

100

ESTIMATED participants

Conditions

Acute Pulmonary Embolism (PE)

Contacts

Doaa Roshdy, assistant lecturer

CONTACT

+201024588594 doaa.elenany@yahoo.com

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Acute Pulmonary Embolism (PE)

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 14, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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