Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of North Carolina, Chapel Hill
With
Northwestern Memorial Hospital
Henry Ford Health System
Yale University
Rush University Medical Center
Dartmouth-Hitchcock Medical Center
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Written informed consent obtained from patient or patient's legally authorized representative (LAR) to participate in the study and HIPAA authorization for release of personal health information.
Subject is willing and able to comply with study procedures based on the judgement of the investigator or protocol designee.
Age ≥ 18 years at the time of consent.
Patient is admitted to the hospital and with a pleural effusion that is drained with a small-bore chest tube or one that allows for administration of IET
Pleural fluid that is one of the following:
(i) Macroscopically purulent or pleural fluid gram stain or culture positive for bacteria (ii) potential of hydrogen (pH) \< 7.2 (iii) Pleural fluid glucose \< 60mg/dL (iv) Pleural fluid Lactate Dehydrogenase (LDH) \> 1,000 IU/L
Patient is deemed a candidate to receive intrapleural enzyme therapy as defined by having a residual collection or persistent sepsis 24 hours after initial chest tube placement
You may not be if
Known pregnancy or lactating females
Prisoners
Age \<18 years at time of consent
Previous treatment with intra-pleural fibrinolytic agents, DNase, or both during the same hospital admission
Known sensitivity or allergic reaction to DNAse or tPA
Coincidental stroke, major hemorrhage (requiring blood transfusions within the last 5 days), major trauma, or major surgery within the last 5 days
Previous pneumonectomy or active bronchopleural fistula on the affected side
Therapeutic systemic anticoagulation or antiplatelet agents that cannot held for more than 48 hours prior to IET administration
Expected survival of less than 3 months due to a pathologic condition other than that causing the pleural infection
Clareo Health | Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema
