PRIMARY OBJECTIVES:
I. Evaluate the role of ONP nicotine concentration on alcohol consumption and side effects during a drinking event.
II. Evaluate the role of ONP flavor on alcohol consumption and side effects of co-use during a drinking event.
III. Describe the effects of ONP nicotine concentration and flavors on next-day side effects after drinking events.
OUTLINE: Participants are randomized to a sequence of 4 ONP with different nicotine concentrations and flavors.
Participants receive four different types of ONPs consisting of low nicotine concentration, high nicotine concentration, unflavored, and spearmint on study. Participants then use the ONPs over 10 days in the order of the assigned sequence for a total of four 10-day periods in the absence of unacceptable toxicity. Participants also complete pre-scheduled ecological momentary assessments (EMAs) over 10 minutes twice daily (BID) and as needed on the mornings after a drinking event during each 10-day ONP use period. Additionally, participants wear an alcohol monitoring wristband for at least 22 hours per day on study.
