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Combined Cyclic Compression Cryotherapy and Phased Rehabilitation Training for Recovery After Knee Replacement

The Efficacy of Cyclic Compression Cryotherapy Combined With Phased Rehabilitation Training on Lower Limb Functional Recovery in Patients After Total Knee Arthroplasty

NCT07089212•Qilu Hospital of Shandong University

View on ClinicalTrials.gov

Summary

Total knee arthroplasty (TKA) is an effective treatment for severe knee joint diseases; however, postoperative complications such as pain, swelling, and delayed functional recovery remain common challenges. Cyclic compression cryotherapy, which applies alternating cold and pressure to the knee joint, can effectively reduce swelling and alleviate pain. Meanwhile, phased rehabilitation training, tailored to the specific recovery stages post-surgery, facilitates targeted exercise interventions to promote functional restoration of the knee joint.

Eligibility

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Diagnosed with knee osteoarthritis (KOA) and within 12 weeks after total knee arthroplasty (TKA).
•2. Aged 18-70 years.
•3. First-time unilateral TKA (non-revision surgery).
•4. Physically and cognitively capable of completing required assessments.
•5. Able to fully adhere to the study protocol.
•6. Willing to participate in and complete the entire rehabilitation program.
•7. No contraindications for surgery or postoperative rehabilitation.
•8. Intact cognitive function (able to provide informed consent and follow instructions).
•9. Available for all follow-up evaluations.

Exclusion Criteria

•1\. Severe cardiovascular or cerebrovascular diseases. 2. Neuromuscular impairments affecting the lower limbs. 3. Concurrent hip or ankle joint disorders. 4. Intolerance to pain (unable to tolerate rehabilitation protocols). 5. Primary or metastatic bone tumors. 6. Rheumatoid arthritis (RA) or other systemic inflammatory arthropathies. 7. Severe obesity (BMI ≥35) or malnutrition (clinically diagnosed). 8. Inability to comply with study assessments (e.g., due to cognitive or physical limitations).
•9\. Visual dysfunction impairing task performance. 10. Functional impairment of the non-operated limb hindering testing/training. 11. Ankylosing spondylitis (AS). 12. History of allergic hypersensitivity to interventions used in the study. 13. Hemorrhagic predisposition (e.g., coagulation disorders, anticoagulant use).
•14\. Active tuberculosis or chronic myelitis. 15. History of substance dependence (e.g., opioids, alcohol). 16. Psychiatric disorders (e.g., schizophrenia, major depression). 17. Severe dysfunction of major organs (e.g., hepatic, renal, pulmonary).

Locations (1)

107 Wenhua Xi Road, Ji'nan Shandong 250012

Jinan, Shandong, China

Key Dates

Start Date

April 23, 2025

Primary Completion Date

May 29, 2025

Completion Date

September 1, 2025

Last Updated

July 28, 2025

Enrollment

100

ESTIMATED participants

Conditions

Knee Arthroplasty, TotalRehabilitation Therapy

Interventions

Phased Rehabilitation Training

BEHAVIORAL

Cyclic Compression Cryotherapy

DEVICE

Conventional rehabilitation treatment.

BEHAVIORAL

Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

NCT07425457

ArthroplastyReplacement Material+4 more

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RECRUITING

Maximal and Self-selected Walkingspeed After Knee Arthroplasty - a Prospective Cohort Study

NCT06847113

Knee Arthroplasty, Total

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 28, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Combined Cyclic Compression Cryotherapy and Phased Rehabilitation Training for Recovery After Knee Replacement

Inclusion Criteria

Exclusion Criteria

Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)

Maximal and Self-selected Walkingspeed After Knee Arthroplasty - a Prospective Cohort Study

Comparison Between Combined Biceps Femoris Short Head Block and Adductor Canal Block Versus Genicular Nerve Block

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The Analgesic Efficacy of Protocol for Primary Total Knee Arthroplasty (TKA)

Shared Decision Aid for Post-Total Knee Arthroplasty Opioid Prescribing