Combination of Concurrent Chemoradiotherapy With Surufatinib and Tislelizumab in Patients With Locally Advanced Non-Small Cell Lung Cancer

Exclusion Criteria

• •Participation in another clinical study, unless it is an observational (non-interventional) study.
• •Histological diagnosis of combined small cell and non-small cell lung cancer.
• •Presence of EGFR or ALK driver gene mutations.
• •Any condition that may affect oral medication administration (e.g., dysphagia, chronic diarrhea, bowel obstruction).
• •Major surgery within 4 weeks prior to study entry (excluding vascular access procedures).
• •Average QT interval corrected for heart rate (QTc) ≥ 470 ms, calculated using Bazett's formula from three ECG cycles.
• •Uncontrolled comorbidities, including but not limited to: ongoing or active infections, symptomatic congestive heart failure, poorly controlled hypertension, unstable angina, clinically significant arrhythmias, active peptic ulcer disease or gastritis, active bleeding disorders, or patients who are HBsAg-positive with HBV DNA \> 500 IU/mL, hepatitis C virus (HCV), or human immunodeficiency virus (HIV) infection. Also excluded are individuals with psychiatric or social conditions that may interfere with study compliance or the ability to provide written informed consent.
• •History of another primary malignancy within 5 years prior to study treatment initiation, except for adequately treated basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix.
• •Pregnant or breastfeeding women; or women and men of reproductive potential who are not using effective contraception.
• •Use of immunosuppressive medications within 28 days prior to the first dose of tislelizumab, excluding intranasal corticosteroids at physiological doses and systemic corticosteroids at a dose equivalent to ≤10 mg/day of prednisone.
• •History of autoimmune disease or active autoimmune disease within the past 2 years.
• •Active or prior history of inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis).
• •History of primary immunodeficiency.
• •History of organ transplantation requiring immunosuppressive therapy.
• •Receipt of a live attenuated vaccine within 30 days prior to study initiation or within 30 days after receiving tislelizumab.
• •Any condition that, in the investigator's judgment, may interfere with the assessment of efficacy or safety of the study treatment.