Bang.an Peng, Master

CONTACT

Lead Sponsor

Shanghai Junshi Bioscience Co., Ltd.

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

No

•Age range: 18 to 80 years old (inclusive), both male and female are acceptable；
•ECOG: 0-2；
•B-cell non-Hodgkin's lymphoma expressing CD20 antigen that has been pathologically diagnosed；
•At least one measurable lesion meeting the criteria specified in the Lugano 2014 response assessment； Acceptable organ function at screening；

•A history of severe allergy to monoclonal antibody therapy (or recombinant antibody-related fusion protein)；
•Previously received CD20-CD3 bispecific antibody treatment；
•Previous allogeneic hematopoietic stem cell transplantation；
•Previous solid organ transplantation；
•History of autoimmune diseases；
•Patients with a history of macrophage activation syndrome (MAS)/ hemophagocytic lymphohistiocytosis (HLH)；
•Patients with a history of progressive multifocal leukoencephalopathy (PML)；
•A known or suspected history of CNS lymphoma (including primary or secondary)；
•There is pleural effusion, peritoneal effusion or pericardial effusion that requires treatment (such as puncture or drainage)；