Lead Sponsor

Universita di Verona

Age

18 - 84 years

Sex

ALL

Healthy Volunteers

Yes

•Age between 18 and 84 years;
•Good general health status;
•Diagnosis of severe periodontitis involving at least 30% of all teeth, with at least three non-adjacent teeth presenting three sites with probing pocket depth (PPD) greater than 4 mm in at least two quadrants, and having lost at least four teeth due to periodontitis;
•Presence of at least 16 teeth, with a minimum of four teeth per quadrant.

•Pregnancy or breastfeeding;
•Presence of decompensated systemic diseases that may compromise the outcomes of the study or the patient's health;
•Regular use of antibiotics;
•Regular use of anti-inflammatory drugs (NSAIDs, corticosteroids, or aspirin);
•Use of anticoagulant medications;
•History of systemic antibiotic therapy within six months prior to enrollment;
•History of any periodontal therapy within six months prior to enrollment;
•Presence of severe mental or cognitive disorders.