CAR19BCMA CAR-T Cells for the Treatment of R/R Plasma Cell Neoplasms

Exclusion Criteria

• •1. Severe heart failure with left ventricular ejection fraction \<50%;
• •2. A history of severe lung function impairment; Combined with other advanced malignant tumors;
• •3. Complicated with severe infection that could not be effectively controlled;
• •4. Severe autoimmune disease or congenital immune deficiency;
• •5. Active viral hepatitis (defined as positive hepatitis B virus DNA \[HBV-DNA\] or hepatitis C virus RNA \[HCV-RNA\] detection, with test results exceeding the lower limit of quantification); Human immunodeficiency virus (HIV) infection or known acquired immunodeficiency syndrome (AIDS), or syphilis infection;
• •6. History of severe allergy to biological products (including antibiotics);
• •7. Allogeneic hematopoietic stem cell transplant patients who still have an acute graft-versus-host response (GVHD) one month after discontinuation of immunosuppressants;
• •8. Patients with other serious physical or mental illnesses or laboratory abnormalities that could increase the risk of participating in the study or interfere with the results of the study, and those who were deemed by the investigator to be unsuitable for participation in the study;
• •9. Female patients (those with fertility) are in pregnancy or lactation.