Age

18–75

Sex

ALL

Healthy volunteers

Not accepted

Histologically confirmed ER-positive , HER2-negative invasive ductal carcinoma meeting at least one of the following:1)T1c-T2 N1 with histological grade 2 (ER 1-10%) or grade 3. 2)N2-N3 or grade 3 and/or Ki67 ≥40%. 3)T3-T4
Age 18-75 years at enrollment
Body mass index (BMI) ≥18.5 kg/m²
Adequate hematological function:1）White blood cell count\>3.0×10⁹/L.2)Absolute neutrophil count ≥1.5×10⁹/L.3)Platelets ≥100×10⁹/L.
Adequate organ function:1）Total bilirubin ≤1.5 × upper limit of normal (ULN).2）ALT/AST ≤2.5 × ULN. 3）Alkaline phosphatase ≤5 × ULN.4）Creatinine clearance ≥50 mL/min-1)
ECOG performance status 0-2
Willing and able to provide written informed consent

Prior history of any malignancy (including contralateral breast cancer)
Received any prior neoadjuvant chemotherapy cycle for current diagnosis
Uncontrolled endocrine disorders:1)Diabetes mellitus requiring insulin or oral hypoglycemics.2)Hyper/hypothyroidism requiring medication
Active autoimmune disease requiring systemic immunosuppressants
Current use of antipsychotic medications
Known hypersensitivity to FMD components (e.g., soy protein, milk protein, nuts)
Pregnancy or lactation.

Fasting-Mimicking Diet as an Adjunct to Neoadjuvant Chemotherapy for Hormone-Receptor-Positive Breast Cancer