Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia

Exclusion Criteria

• •Emergency surgery;
• •Contraindication to non-steroidal anti-inflammatory drugs: history of gastro duodenal ulcer, renal failure from stage 3 A or higher;
• •History of bradycardia and/or known conduction disorder (atrioventricular block) / Pacemaker ;
• •Unstable coronary ;
• •Myocardial infarction \<6 months;
• •Severe cardiocirculatory insufficiency;
• •Severe hepatic insufficiency;
• •Allergy to morphine ;
• •Allergy to lidocaine;
• •Rhythm disorders at risk of sudden death (e.g. Brugada syndrome);
• •Flecaine as usual treatment;
• •Chronic pain with level II or III analgesics;
• •Gabapentinoids: pregabalin (Lyrica), gabapentin;
• •Drug addiction and substitute drugs;
• •Epileptic disorders ;
• •Myasthenia gravis;
• •Creatinine clearance below 10 mL/min;
• •Hypokalemia, hypoxia or acid-base disorders;
• •Patient participating in another clinical trial, or in a period of exclusion from another clinical trial;
• •Inability to understand study information (due to linguistic, psychological, cognitive or literacy problems);
• •Women who are or may become pregnant\* (of childbearing age, without effective contraception) or who are breast-feeding;
• •Patient deprived of liberty, under guardianship or unable to give consent.