Loading clinical trials...

The Effect of SSRIs on Threat of Shock Potentiated Neural Circuitry | Clinical Trials | Clareo Health

COMPLETEDNA

The Effect of SSRIs on Threat of Shock Potentiated Neural Circuitry

NCT07074652•UCLH/UCL Joint Research Office

Summary

This study aims to increase the knowledge about psychological processes which may contribute to mental health problems such as depression and anxiety. This study aims to investigate if administering Escitalopram, an antidepressant which increases serotonin levels in parts of the brain, affects how the brain processes emotional information. It is hoped that measuring these changes will increase the understanding of processes involved in mental health problems.

Eligibility

Age

18 - 50 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Healthy Controls:
•Fluency in English
•Registration with a UK General Practitioner
•Capacity for consent
•No personal history of long-term medical conditions or psychiatric illness (including substance dependence, assessed with the Mini International Neuropsychiatric Interview)
•Anxious Individuals:
•Fluency in English
•Registration with a UK General Practitioner
•Capacity for consent
•Meeting criteria for generalised anxiety disorder, panic disorder and/or agoraphobia (also assessed with the Mini International Neuropsychiatric Interview); permitted comorbid conditions were: major depressive disorder, obsessive-compulsive disorder and/or post-traumatic stress disorder

Exclusion Criteria

•Healthy Controls and Anxious Individuals:
•Having consumed alcohol within 12 hours prior to the study
•having used illicit drugs within 3 months prior to the study
•Having had any contraindications to MRI scanning
•Being pregnant or breastfeeding
•Having had impaired or uncorrected vision or hearing

Locations (1)

University College London

London, United Kingdom

Key Dates

Start Date

December 1, 2017

Primary Completion Date

June 30, 2022

Completion Date

June 30, 2022

Last Updated

July 20, 2025

Enrollment

145

ACTUAL participants

Conditions

Anxiety

Interventions

Escitalopram

DRUG

Placebo

DRUG

Readiness and Progress in Emotion Regulation Therapy

NCT07478393

RuminationWorry+4 more

View study

RECRUITINGNA

ACTsocially: The (Dis)Similarities of ACT for Changing Internalizing and Externalizing Symptomatology in Adolescence

NCT07456631

Social Anxiety Disorder (SAD)Oppositional Defiant Disorder

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 20, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

The Effect of SSRIs on Threat of Shock Potentiated Neural Circuitry

Inclusion Criteria

Exclusion Criteria

Readiness and Progress in Emotion Regulation Therapy

ACTsocially: The (Dis)Similarities of ACT for Changing Internalizing and Externalizing Symptomatology in Adolescence

"Erectile Function After PCI in MI and Non-MI Patients"

In Vivo Exposure vs. Videochat-Based Vicarious Exposure

Transcranial Alternating Current Stimulation for Generalized Anxiety Disorder and Insomnia: An Open-Label Pilot Study

Effects of Darkness Retreat: a Pilot Study