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Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms | Clinical Trials | Clareo Health

RECRUITINGNA

Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

NCT07069478•University of Minnesota

Summary

The aim of this study is to determine the effects of regular cannabidiol (CBD) use on the psychobiological mechanisms of the stress response. This will be achieved by comparing acute stress responses of adults who either use or do not use CBD regularly. Correlates of CBD use, including tobacco use, will be collected.

Eligibility

Age

21 - 70 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Adults who are relatively healthy and aged 21-70 years.
•Must keep a normal sleep schedule (sleep during nighttime, awake during daytime).
•Must either (1) use CBD daily/regularly or (2) not use CBD regularly.

Exclusion Criteria

•Participated in previous acute stress studies that included a similar stress induction.
•Current, unstable: major psychiatric disorder or medical condition (e.g., uncontrolled hypertension above 160/100).
•Self-reported current pregnancy.
•Self-reported current use of illicit substances (other than cannabis).
•Non-compliance with instructions for study visit (abstinence from alcohol, caffeine, physical activity, etc.)
•Students of the principal researcher

Locations (1)

University of Minnesota

Minneapolis, Minnesota, United States

Key Dates

Start Date

June 1, 2025

Primary Completion Date

November 30, 2026

Completion Date

November 30, 2026

Last Updated

July 16, 2025

Enrollment

125

ESTIMATED participants

Conditions

CBDCannabidiolStressAcute Stress Reaction

Interventions

Stress Intervention

OTHER

Contacts

Stress and Resilience Research Labs

CONTACT

2187268623 umdbml@d.umn.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 16, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Cannabidiol (CBD) and Stress Response: Psychobiological Mechanisms

Inclusion Criteria

Exclusion Criteria

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