6 Weeks Right-Amygdala TIS for Depression

Exclusion Criteria

• •Comorbidities : Major psychiatric disorders (e.g., schizophrenia, bipolar disorder) Significant neurological conditions (e.g., traumatic brain injury, post-neurosurgical status)
• •Medical Devices : Intracranial/cardiac metallic implants or electronic medical devices (e.g., pacemakers, deep brain stimulation systems)
• •Recent Interventions : Electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), or other neuromodulation therapies within 30 days prior to enrollment
• •Clinical Instability : Acute suicidality (e.g., active suicidal ideation with intent) Inability to complete study follow-up per investigator judgment
• •Concurrent Trials : Participation in other interventional clinical studies during the trial period
• •Reproductive Status : Pregnancy, lactation, or plans for conception during the trial
• •Suicide Risk : Score ≥3 on Item 3 of the 17-item Hamilton Depression Rating Scale (HAMD-17)
• •Any condition deemed to compromise subject safety or study validity per clinical evaluation