Loading clinical trials...

Compare the Effectiveness of nVNS and TENS on Pain and Quality of Life in Patients of Migraine | Clinical Trials | Clareo Health

ACTIVE_NOT_RECRUITINGNA

Compare the Effectiveness of nVNS and TENS on Pain and Quality of Life in Patients of Migraine

Compare the Effectiveness of Non-invasive Vagus Nerve Stimulation (nVNS) and Non-invasive Transcutaneous Electrical Nerve Stimulation (TENS) on Pain and Quality of Life (QOL) in Patients of Migraine: a Randomized Control Trial

NCT07055776•Superior University

View on ClinicalTrials.gov

Summary

Migraine is a genetically influenced complex neurological disorder characterized by episodes of moderate-to-severe headaches, typically unilateral and frequently accompanied by nausea and heightened sensitivity to light and sound. The common type of migraine headaches is migraine without aura. Migraine has an approximate prevalence of 14.7%, making it the third most common disease in the world. This study aims to compare the effectiveness of non-invasive vagus nerve stimulation (nVNS) and non-invasive transcutaneous electrical nerve stimulation (TENS) in managing pain and improving quality of life (QOL) in patients with migraine.

Eligibility

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•People will be eligible for participation of 18-75 years of age.
•Participants are included with previous diagnosis of migraine with aura according to ICHD-3 beta criteria.
•Patients who had 15 headache days per month over the last 6 months will be included in this study.

Exclusion Criteria

•Participants with a history of secondary headaches,
•aneurysms, brain tumors, significant head trauma
•substance abuse, cardiovascular or cerebrovascular disease
•uncontrolled hypertension, psychiatric disorders,
•pregnancy, steroid use, botulinum toxin injections in the past 6 months, or certain other medical conditions were excluded.
•individuals with excessive use of pain medications, recent preventive treatments, or previous surgeries and procedures related to migraines will not be eligible.

Locations (1)

Chaudary Muhammad Akram Teaching Hospital, Azra Naheed Medical College, Superior University

Lahore, Punjab Province, Pakistan

Key Dates

Start Date

March 17, 2025

Primary Completion Date

September 1, 2025

Completion Date

February 28, 2026

Last Updated

July 9, 2025

Enrollment

ACTUAL participants

Conditions

Migraine

Interventions

non-invasive vagus nerve stimulation (nVNS)

COMBINATION_PRODUCT

non-invasive transcutaneous electrical nerve stimulation (TENS)

COMBINATION_PRODUCT

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

NCT07018713

Chronic Migraine

View study

RECRUITINGPHASE3

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

NCT06641466

Menstrual Migraine

View study

RECRUITINGNA

Mind Body Balance for Pediatric Migraine

NCT04715685

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 9, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Compare the Effectiveness of nVNS and TENS on Pain and Quality of Life in Patients of Migraine

Inclusion Criteria

Exclusion Criteria

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

Mind Body Balance for Pediatric Migraine

Light Exposure, Migraine Outcomes, and Sleep Quality

A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine

Prophylactic Treatment With Atorvastatin for Episodic Migraine.