Prophylactic Treatment With Atorvastatin for Episodic Migraine.

Exclusion Criteria

• •Interval headache not distinguishable from migraine.
• •Chronic migraine, chronic tension-type headache, medication overuse headache or other headache occurring on ≥ 15 days/month.
• •Pregnancy, planning to get pregnant, inability to use contraceptives, and lactating.
• •Clinical information on or signs of cholestasis or decreased hepatic or renal function.
• •High degree of comorbidity and/or frailty associated with reduced life expectancy or high likelihood of hospitalization, at the discretion of the investigator.
• •Hypersensitivity to statins or previous use of statins.
• •History of angioneurotic oedema.
• •Use of medicines for migraine prophylaxis less than 4 weeks, or of botulinum toxin less than 16 weeks, prior to start of study.
• •Current use of antiviral treatment against hepatitis C.
• •Significant psychiatric illness.
• •Having tried ≥ 3 prophylactic drugs against migraine during the last 10 years.
• •Requiring detoxification from acute medication (triptans, opioids).
• •Consistently failing to respond to any acute migraine medication.
• •Alcohol or illicit drug dependence.
• •Inability to understand study procedures and to comply with them for the entire length of the study.
• •Treatment for hypothyroidism.
• •Lactose intolerance.