CtDNA-guided Maintenance Therapy in Pancreatic Cancer

Exclusion Criteria

• •Prior history of radiotherapy, chemotherapy or surgical treatment for pancreatic cancer
• •Concurrent severe organ dysfunction or hematologic disorders
• •Tumor involvement of celiac axis or superior mesenteric artery, locally advanced disease, or presence of distant metastases
• •Poor general condition deemed unable to tolerate chemotherapy
• •History of other malignancies within past 5 years (except adequately treated carcinoma in situ of cervix or basal cell carcinoma of skin)
• •Any severe or uncontrolled systemic disease that may affect risk/benefit assessment, including but not limited to: uncontrolled hypertension, active hepatitis B or C infection, HIV infection
• •Patient or guardian unable to comprehend study objectives and requirements
• •Any other condition that in the investigator's judgment would make the patient unsuitable for study participation