Curcumin, Vitamin D and Green Tea in IBS-D

Exclusion Criteria

• •1. Prior abdominal surgery other than appendectomy and cholecystectomy.
• •2. Known hypercalcaemia.
• •3. Participating in another trial or taken an IMP within the last 1 month.
• •4. Females who report to be pregnant or lactating
• •5. Unwilling to maintain stable doses of permitted concomitant medication
• •6. Unwilling to maintain a stable diet for the duration of the trial
• •7. Being in the opinion of the investigator unsuitable
• •8. Insufficient knowledge of English to complete the daily bowel diary and food diary
• •9. Hypersensitivity to any component of the supplement
• •10. Hypersensitivity or known allergy to lactulose
• •11. Drug interactions with any component of the supplement
• •12. Consumption of antibiotics, prebiotics or probiotics (in food products or as supplements) in the last 4 weeks prior to, or during the study.
• •13. Vitamin D two week washout
• •14. Participants who have received bowel preparation for investigative procedures in the 4 weeks prior to the study
• •15. Individuals declaring additional specific dietary needs
• •16. Inflammatory bowel disease or coeliac disease
• •17. Any other condition, deemed by the investigator, that may be causing their symptoms
• •18. No major co-morbidity.
• •19. Participant is involved in this study as an Investigator, sub-Investigator, study coordinator, other study staff, or Sponsor member.