Contrast Enhanced Ultrasound in Neurosurgery to Improve Glioma Visualization and Border Demarcation

Exclusion Criteria

• •Patient at high risk of surgical site infection (e.g., 2 or more previous craniotomies/neurosurgery within the last 3 months, poor skin condition, and/or previously infected surgical field, or any other condition that is of increased infectious risk in the opinion of the neurosurgeon)
• •Known history of hypersensitivity reactions to perflutren lipid microsphere components or to any of the inactive ingredients in the contrast agent.
• •Patient with known or suspected active or chronic infections.
• •Patient with known significant cardiac disease, known to have right-to-left shunts, severe pulmonary hypertension (pulmonary artery pressure \> 90 mm Hg), uncontrolled systemic hypertension, or adult respiratory distress syndrome.
• •Pregnant, or breastfeeding patient.
• •Patient with known sickle cell disease.
• •Any other serious patient medical or psychological condition that may interfere with adequate and safe delivery of treatment and care.
• •Patients under guardianship, curatorship, under legal protection or deprived of liberty by an administrative or judicial decision.