Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

Unifocal infiltrating ductal breast carcinoma, non-special histotype
clinical stage T1-T2,N0
No contraindications to MRI, or metal joint prostheses from knee to shoulder included, or femoral stent.
Patients aged \>18 years
Good general condition (ECOG 0-2)
Expected active treatment (crioablation or surgery or radiotherapy ).

* Nodule involvement and metastasis (cN1 and/or cM1)
* Concomitant inflammation of the intestine
* Significant systemic diseases or ongoing oral anticoagulant therapy
* Non-compliance of dose constraints in the treatment plan
* Previous invasive cancer, unless the patient has had no disease for at least 3 years
* Mental disorders that cannot ensure valid informed consent
Histology other than non-special histotype and non-epithelial tumors (sarcoma, lymphoma)
Male sex
High-risk mutation carrier patients
Bilateral breast cancer
synchronous distant metastases
Neoadjuvant therapy
autoimmune connective tissue diseases
previous radiotherapy to the chest
Mental disorders that cannot ensure valid informed consent
No previous thoracic radiotherapy

Personalization of External Beam Radiation Therapy in Localised Tumours