Methoxyflurane for IUD Insertion and Endometrial Biopsy

Exclusion Criteria

• •Use of pain medication that is not an NSAID or acetaminophen (e.g. opioids, benzodiazepines) within past 24 hours
• •Misoprostol administration within 24 hours
• •Breastfeeding
• •Any diagnosed chronic pain syndromes (e.g. fibromyalgia, vaginismus)
• •Allergy to methoxyflurane
• •Renal or liver disease
• •Known or genetically susceptible to malignant hyperthermia or a history of severe adverse reactions in either patient or relatives
• •Baseline vital signs of systolic blood pressure \<100, diastolic blood pressure \<60 and/or pulse \<60.
• •Previous unsuccessful office attempt of IUD insertion or endometrial biopsy by the same practitioner (note of clarification: previous unsuccessful IUD insertion or biopsy attempt by a different practitioner will still be eligible)
• •Clinically evident respiratory impairment