Assessing An Oral JAK1 Inhibitor, Golidocitinib, in Patients Who Have Newly Diagnosed Peripheral T-Cell Lymphoma (JACKPOT23)

Exclusion Criteria

• •1. Intervention with any of the following:
• •* Any investigational anti-cancer agents or study anti-cancer drugs from a previous clinical study.
• •* Any cytotoxic chemotherapy from a previous treatment regimen.
• •* Corticosteroids at dosages equivalent to prednisone \> 40 mg/day within 7 days.
• •2. Major surgery procedure, or significant traumatic injury within 4 weeks.
• •3. Prior treatment with a JAK or STAT3 inhibitor.
• •4. Prior treatment with any onco-immunotherapy in 28 days.
• •5. Live vaccines within 28 days.
• •6. Patients currently receiving (or unable to stop use at least 14 days prior to receiving the first dose) medications or herbal supplements known to be Potent inhibitors or inducers of CYP3A.
• •7. Central nervous system or leptomeningeal lymphoma.
• •8. Past medical history of pneumonitis, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease.
• •9. Patients with disease condition which requires the treatment of immunosuppressants, biologics, or NSAID.
• •10. Active infections
• •11. Clinically significant cardiac disorders or abnormalities. Acute thrombotic diseases within 90 days.
• •12. Another malignancy within 5 years prior to enrollment with the exception of adequately treated in-situ carcinoma of the cervix, uterus, basal or squamous cell carcinoma or nonmelanomatous skin cancer.
• •13. Gastrointestinal disorders that is inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of golidocitinib.
• •14. History of hypersensitivity to active or inactive excipients of golidocitinib or drugs with a similar chemical structure or class.
• •15. Women who are breast feeding or pregnant.