Lead Sponsor

Eli Lilly and Company

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

•W8M-MC-GN02:
•Assigned male at birth
•Assigned female at birth, who are of non-childbearing potential
•Have type 2 diabetes
•W8M-MC-CWMM:
•Have a BMI ≥27 kilograms per square meter (kg/m²)
•Have had a stable body weight for the 3 months prior to randomization (\<5% body weight gain and/or loss

•W8M-MC-GN02:
•Individuals who are of childbearing potential
•Have a history of acute or chronic pancreatitis
•Have any of the following cardiovascular conditions within 6 months prior to screening:
•* acute myocardial infarction
•* cerebrovascular accident (stroke)
•* unstable angina, or
•* hospitalization due to congestive heart failure.
•W8M-MC-CWMM:
•Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed \>1 year prior to screening
•Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma
•Have poorly controlled hypertension
•Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease
•Have a history of symptomatic gallbladder disease within the past 2 years
•Have a lifetime history of suicide attempts

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