Measurable or non measurable cancer that the research can assess for changes
You may not be if
Availability of a part of a tumor for laboratory testing or willing to have a safe biopsy taken from a tumor
Diagnosed with locally advanced, recurrent or metastatic incurable disease
Part 1: any solid tumor (with the exception of brain cancer) that has progressed, standard therapy is no longer or has not helped the cancer, or is too toxic and for whom a clinical trial is an option for continued treatment
Part 1: specific advanced, metastatic tumor types will also be enrolled: colorectal cancer, small cell lung cancer, head and neck cancer, non-small cell lung cancer, pancreatic cancer, bladder cancer - some of these will have a specific gene mutation in the cancer
Part 1: selected solid tumor cancer types (with the exception of brain cancers) that have a specific gene mutation in the cancer
Part 2: specific advanced, metastatic tumor types will also be enrolled: colorectal cancer, small cell lung cancer, head and neck cancer - some of these will have a specific gene mutation in the cancer
\_ Part 2: selected solid tumor cancer types (with the exception of brain cancers) that have a specific gene mutation in the cancer
Adequate blood and urine lab tests
Women and men of childbearing potential with adequate contraception
Provides written informed consent
Willing to comply with the requirements of the protocol
Inability to swallow pills
Known history of HIV, HCV, HBV unless cured, controlled with undetectable viral load
Active tumor in the brain
Clinically significant liver disease
Significant gastrointestinal diseases
History of other cancer within past 5 years with certain exceptions for cancers that are likely cured
Significant cardiac disease
Other diseases that are not well controlled that could make taking the drug unsafe
pregnant or lactating females
Exposure to certain anti-cancer or other drugs within a certain period before the start of study drug
Clareo Health | Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
