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Early Luteal Phase Progesterone Kinetics After hCG-Induced Ovulation in Modified Natural Cycle | Clinical Trials | Clareo Health

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Early Luteal Phase Progesterone Kinetics After hCG-Induced Ovulation in Modified Natural Cycle

Evolution of Luteal Progesteronemia in a Modified Natural Cycle (Ovulation Triggered by hCG): Pilot Study

NCT07028710•University Hospital, Montpellier

View on ClinicalTrials.gov

Summary

This pilot study evaluates how progesterone levels change after hCG-triggered ovulation in modified natural cycles. Forty women preparing for frozen embryo transfer will have blood tests over 6 days to monitor hormone levels. The goal is to understand whether hCG affects the timing of the luteal phase and embryo implantation.

Eligibility

Age

All ages

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•At least 1 follicle of 17 mm or more
•Endometrium of 6 mm or more
•Plasma luteinizing hormone (LH) less than 2 times basal level (measured at the beginning of the cycle between D1 and D4) and progesteronemia less than 1.5 ng/mL
•For whom ovulation induction with recombinant hCG (Ovitrelle) is then proposed (standard care).
•care)

Exclusion Criteria

•Patient whose venous capital contraindicates repeated blood sampling over a short period of time over a short period.
•Patient treated with exogenous natural progesterone (vaginal or injectable) which may interfere or synthetic progesterone, which may interfere with endogenous progesterone secretion.
•Patient who has not given written consent to participate in the study.
•Patient not fluent in French.
•Patient under guardianship, curators or without social security coverage.
•Patient participating in another study with an ongoing exclusion period or other interventional research with no ongoing exclusion period involves the use of a drug or procedure capable of altering progesterone levels .

Key Dates

Start Date

January 15, 2026

Primary Completion Date

June 15, 2028

Completion Date

June 15, 2030

Last Updated

November 28, 2025

Enrollment

ESTIMATED participants

Conditions

Luteal Phase Insufficiency

Interventions

hCG

DRUG

Contacts

Noémie RANISAVLJEVIC, Senior Lecturer - Hospital Pra

CONTACT

04 67 33 64 81 n-ranisavljevic@chu-montpellier.fr

Anne CADENE, Project manager

CONTACT

04.67.33.08.14 a-cadene@chu-montpellier.fr