The Efficacy and Safety of Acupuncture for Prophylaxis of Menstrually Related Migraine

Exclusion Criteria

• •1. irregular menstrual cycles, defined as cycle length outside the range of 28±7 days or menstruation duration \<3 days or \>7 days;
• •2. presence of secondary headache disorders, facial neuralgia, or cranial neuralgia;
• •3. combined with serious primary diseases such as cardiovascular, hepatic, renal, gastrointestinal, or hematological disorders that may interfere with the treatment protocol, or comorbid neurological conditions such as epilepsy, parkinson's disease, or other central nervous system disorders;
• •4. headache symptoms caused by other conditions, such as moderate to severe head or neck trauma, perimenstrual infections, intracranial tumors, intracranial infections, endocrine or metabolic disorders;
• •5. receipt of preventive treatment for headache within 1 month prior to the screening visit;
• •6. afraid of needles or received acupuncture treatment within 3 months;
• •7. unwillingness to undergo the study intervention or failure to sign the informed consent.