Protoporphyrin Imaging in Multispectral Evaluation of Resections

Inclusion Criteria

• •Age Requirement: Patients must be 18 years of age or older.
• •Diagnosis: Patients with a preoperative diagnosis of a suspected high-grade glioma based demographics and MRI imaging.
• •MRI Findings: Patients must meet one of the following criteria:
• •* Group 1: Suspected high-grade glioma with contrast enhancement on MRI (GBM-like).
• •* Group 2: Suspected high-grade glioma without contrast enhancement on MRI (LGG-like).
• •Surgical Resection: Patients scheduled to undergo surgical resection of the tumor as part of standard treatment.
• •5-ALA Administration: Patients who will receive 5-aminolevulinic acid (5-ALA) for fluorescence guidance during surgery.
• •Post-op MRI: Patients who are able to undergo pre- and postoperative MRI (standard of care at the center).
• •Informed Consent: Patients who are able to understand and provide written informed consent prior to enrollment in the study.
• •Eligibility for Multispectral Imaging: Patients whose surgical procedures allow for the use of multispectral imaging technology for tumor visualization.
• •Performance Status: Patients with a Karnofsky Performance Status (KPS) of 60 or greater, indicating that they are capable of at least limited self-care.
• •No Prior Treatment: Patients who have not received prior treatment for the current brain tumor, including surgery, radiotherapy, or chemotherapy.