A Study to Evaluate the Safety, Tolerability and PK of SK-08

Exclusion Criteria

• •1. Have a specific history of allergies or have an allergic constitution；
• •2. Have a history of chronic diseases or severe diseases in the cardiovascular, liver, kidney, biliary tract, respiratory, blood and lymphatic, endocrine, immune, mental, neuromuscular, gastrointestinal systems, etc.
• •3. Developed acute diseases from 2 weeks before screening to before randomization ;
• •4. Patients with previous or current hypotension or insufficient blood volume, intracranial hypertension or cerebral hemorrhage, or those with ocular diseases (such as angle-closure glaucoma), who are not suitable for inclusion after assessment by the researcher;
• •5. Those with clinical significance hypokalemia, hyperkalemia, hypomagnesemia, hypermagnesemia, hypocalcemia, and hypercalcemia;
• •6. Those who have used any drugs or health supplements from 2 weeks before screening to randomization ;
• •7. Any drugs that may interact with this product have been used from 30 days before screening to randomization, such as CYP450 inhibitors or inducers ;
• •8. Those who have undergone major surgical operations from 6 months before screening , or who plan to undergo surgery during the study period, or who have undergone surgeries as judged by the investigator to affect drug absorption, distribution, metabolism, and excretion;
• •9. Those who have received live attenuated vaccine inoculation from 2 weeks before screening to randomization or those who need to receive live attenuated vaccine inoculation during the trial;
• •10. Those who had a history of alcohol abuse within one year before screening；
• •11. Those who smoked more than 5 cigarettes per day on average within 3 months before screening and before randomization, or were unable to stop using any tobacco products during the trial period;
• •12. Those who cannot tolerate venipuncture/indwelling needles or have a history of fainting from needles or blood ;
• •13. Other researchers determined that the subjects were not suitable to participate.