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A Phase 1, Randomized, Double-Blind, Third-Party-Unblinded Trial to Evaluate the Safety and Immunogenicity of 20-valent Pneumococcal Conjugate Vaccine (20vPnC) and 13-valent Pneumococcal Conjugate Vaccine (13vPnC) in Pneumococcal Vaccine-Naïve Adults 50 Years of Age and Older in China
This Phase 1, randomized, double-blind, third-party-unblinded study will be conducted at investigational sites in China. The purpose of the study is to learn about the safety and immune response of 20vPnC and 13vPnC in Chinese adults 50 years of age and older who did not receive any of pneumococcal vaccine in the past
The purpose of the study is to learn about the safety and immune response of 20vPnC and 13vPnC vaccines in Chinese adults. This study is seeking for participants who: * are 50 years of age and older * did not receive any of vaccines used to treat infections caused by the bacteria called Streptococcus pneumonia in the past. The participants will be grouped by three age groups: * Adults between 50 to 59 years of age * Adults between 60 to 64 years of age * Adults who are 65 years of age or above All participants in this study will receive a single dose of 20vPnC or 13vPnC at study clinic. The study will look at the experiences of people receiving 20vPnC and 13vPnC. This will help decide if the study vaccine is safe. The total duration of taking part in the study will be around 6 months, with 6 visits.
Age
50 - No limit years
Sex
ALL
Healthy Volunteers
Yes
Zhejiang provincial center for disease control and prevention
Hangzhou, Zhejiang, China
Kaihua County Center For Disease Prevention and Control
Kaihua, Zhejiang, China
Kaihua County Center For Disease Prevention and Control
Quzhou, Zhejiang, China
Start Date
July 6, 2025
Primary Completion Date
January 28, 2026
Completion Date
January 28, 2026
Last Updated
February 25, 2026
400
ACTUAL participants
20vPnC
BIOLOGICAL
13vPnC
BIOLOGICAL
Lead Sponsor
Pfizer
NCT06731374
NCT06044077
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT06790290