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Comparison of Methods of Weaning From Nasal CPAP in Preterm Infants: A Randomized Controlled Trial | Clinical Trials | Clareo Health

COMPLETEDNA

Comparison of Methods of Weaning From Nasal CPAP in Preterm Infants: A Randomized Controlled Trial

NCT07009366•RESnTEC, Institute of Research

View on ClinicalTrials.gov

Summary

This study aimed to determine the efficacy of different NCPAP weaning strategies in pre-term infants presenting with respiratory distress, and ultimately establishing the best method to withdraw from NCPAP.

Detailed Description

Pakistan, as well as other developing countries, lacks data regarding the weaning protocol of NCPAP. Ascertaining the best weaning method that could facilitate a shorter duration on nasal CPAP and the least length of hospital stay is very much needed. Findings of this study would help clinicians to achieve better outcomes for the patients receiving nasal CPAP.

Eligibility

Age

0 - 0 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Preterm infants
•Any gender
•Low birth weight
•Gestational ages between 28 to below 37 weeks
•Presented with respiratory distress
•Neonates with radiological findings suggestive of respiratory distress, congenital pneumonia/sepsis, or transient tachypnea of the newborn (TTN)

Exclusion Criteria

•Complex congenital abnormalities like diaphragmatic hernia, CNS malformations, intrapartum-related hypoxia, or congenital heart disease.
•Intraventricular hemorrhage grade III or IV or low APGAR scores (\<4 or 5 at 5 minutes)

Locations (1)

Ziauddin University

Karachi, Sindh, Pakistan

Key Dates

Start Date

July 1, 2024

Primary Completion Date

December 31, 2024

Completion Date

December 31, 2024

Last Updated

June 6, 2025

Enrollment

ACTUAL participants

Conditions

Respiratory Distress Syndrome, Newborn

Interventions

Sudden weaning of NCPAP

PROCEDURE

Gradual weaning with increasing the time off NCPAP

PROCEDURE

Pressure weaning of NCPAP

PROCEDURE

Prophylactic Minimally Invasive Surfactant Evaluation

NCT06007547

Respiratory Distress Syndrome, NewbornPremature Birth

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COMPLETED

Predictors for Nasal Intermittent Positive Pressure Ventilation Failure for Premature Infants With Respiratory Distress Syndrome

NCT05260424

Respiratory Distress Syndrome, NewbornPremature

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 6, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Comparison of Methods of Weaning From Nasal CPAP in Preterm Infants: A Randomized Controlled Trial

Inclusion Criteria

Exclusion Criteria

Prophylactic Minimally Invasive Surfactant Evaluation

Predictors for Nasal Intermittent Positive Pressure Ventilation Failure for Premature Infants With Respiratory Distress Syndrome

Feasibility Study of Placement and Surfactant Administration Through a Preterm Size Laryngeal Mask Airway in Very Low Birth Weight Neonates With Respiratory Distress Syndrome

Delivery Room Management Trial of Premature Infants at High Risk of Respiratory Distress Syndrome

Aerosolized Surfactant in Neonatal RDS

A Double Blind, Randomized, Controlled Study to Evaluate CHF 5633 (Synthetic Surfactant) and Poractant Alfa in Neonates With Respiratory Distress Syndrome (RDS) (POC)