Precision Medicine Applied to the Study of Endometrial Cancer: Application of NGS for Molecular Classification

Exclusion Criteria

• •The following uterine neoplasms will be excluded:
• •* Biphasic tumors (epithelial-mesenchymal) such as adenosarcoma.
• •* Mesenchymal neoplasms such as endometrial stromal sarcoma and leiomyosarcomas.
• •* Others: primary lymphoproliferative processes of the uterine body; neuroendocrine tumors; Gestational trophoblastic disease, secondary lesions either of the genital tract (example: cervical carcinomas with extension to the endometrium) or of distant sites (breast cancer metastasis).
• •* Patients with synchronous endometrial and ovarian carcinoma
• •* For technical reasons, they will be excluded
• •* tumors smaller than 0.2 cm in which sufficient material cannot be obtained for immunohistochemical and molecular biology determinations.
• •* Tumors with severe artifacts due to poor processing, such as autolysis.
• •* Samples with low-quality DNA
• •* Patients operated on outside participating centers.
• •* Patients under 18 years of age.
• •* Patients with primary non-surgical treatments (neoadjuvant chemotherapy).