PARAtracheal vs CRIcoid Pressure on GLIttic DEformation (PARAGLIDE)

This randomized crossover trial will compare three laryngoscopy conditions (no pressure, cricoid pressure, left paratracheal pressure) in adult surgical patients requiring general anesthesia with tracheal intubation. Each patient undergoes all three conditions in random order, with the intubation performed using the maneuver chosen by the operator. Anatomical outcomes (POGO, glottic surface area, vertical and horizontal displacement of the glottic plane) will be assessed from video recordings by blinded evaluators. Clinical outcomes (first-pass success, composite success without desaturation \<90%, intubation time, IDS, hypoxemia, hemodynamic changes, airway trauma, sore throat, dysphonia) will be collected from routine anesthetic records and PACU assessments. Statistical Analysis Plan: POGO: mixed-effects repeated measures model with patient as random effect, maneuver as fixed effect, adjusted for operator, BMI, and Mallampati. Anatomical outcomes: analyzed similarly with mixed models and planned contrasts (LPP vs CP). Clinical outcomes: analyzed as-treated, using logistic or linear regression with adjustments for baseline factors and operator as random effect. Mediation analysis will evaluate whether improvements in POGO explain clinical benefits (first-pass success, intubation time). Significance level set at α=0.05 (two-sided), with exploratory outcomes interpreted without multiplicity correction. Missing data (e.g., unusable videos, missing sore throat scores) will be reported; complete-case analysis will be primary, sensitivity analysis considered if \>5% missing.